CCL5(C-C motif chemokine ligand 5)もしくはRANTES(regulated on activation, normal T cell expressed and secreted)は、ヒトではCCL5遺伝子にコードされるタンパク質である[5]。CCL5遺伝子は1990年にin situハイブリダイゼーションによって発見され、染色体上では17q11.2-q12に位置している遺伝子である[6]。RANTESという名称は最初に記載を行ったTom Schallによって命名されたもので、アルゼンチン映画「(南東からきた男)(英語版)」で精神病棟に現れたRantésという名の宇宙人から取ったものである[7]。
^“Localization of a human T-cell-specific gene, RANTES (D17S136E), to chromosome 17q11.2-q12”. Genomics6 (3): 548–553. (March 1990). doi:10.1016/0888-7543(90)90485-D. hdl:(2027.42/28717). PMID (1691736).
^ abcd“Functional roles of CCL5/RANTES in liver disease”. Liver Research4 (1): 28–34. (2020-03-01). doi:10.1016/j.livres.2020.01.002.
^“Hooked on HIV - What's the connection between a 1980s film character and the cutting edge of AIDS research? Philip Cohen reports on a protein that's unlocking HIV's mysteries”. Copyright New Scientist Ltd. (1996年12月14日). 2022年12月25日閲覧。
^ abcdef“RANTES: a versatile and controversial chemokine” (英語). Trends in Immunology22 (2): 83–87. (January 2001). doi:10.1016/S1471-4906(00)01812-3. PMID (11286708).
^“CC chemokines induce the generation of killer cells from CD56+ cells”. European Journal of Immunology26 (2): 315–319. (February 1996). doi:10.1002/eji.1830260207. PMID (8617297).
^ ab“Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells”. Science270 (5243): 1811–1815. (December 1995). Bibcode: 1995Sci...270.1811C. doi:10.1126/science.270.5243.1811. PMID (8525373). https://zenodo.org/record/1231052.
^Alan M. Krensky (1995). Biology of the Chemokine in Rantes (Molecular Biology Intelligence Unit). R G Landes Co.. ISBN (978-1-57059-253-9)
^“RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes”. Immunity10 (1): 93–103. (January 1999). doi:10.1016/S1074-7613(00)80010-2. PMID (10023774).
^“Transcriptional regulation of RANTES expression in T lymphocytes”. Immunological Reviews177: 236–245. (October 2000). doi:10.1034/j.1600-065X.2000.17610.x. PMID (11138780).
^“JNK MAPK pathway regulates constitutive transcription of CCL5 by human NK cells through SP1”. Journal of Immunology182 (2): 1011–1020. (January 2009). doi:10.4049/jimmunol.182.2.1011. PMID (19124744).
^“RANTES production by memory phenotype T cells is controlled by a posttranscriptional, TCR-dependent process”. Immunity17 (5): 605–615. (November 2002). doi:10.1016/S1074-7613(02)00456-9. PMID (12433367).
^Vangelista, Luca; Secchi, Massimiliano; Liu, Xiaowen; Bachi, Angela; Jia, Letong; Xu, Qiang; Lusso, Paolo (2010-07). “Engineering of Lactobacillus jensenii to secrete RANTES and a CCR5 antagonist analogue as live HIV-1 blockers”. Antimicrobial Agents and Chemotherapy54 (7): 2994–3001. doi:10.1128/AAC.01492-09. ISSN 1098-6596. PMC 2897324. PMID (20479208). https://pubmed.ncbi.nlm.nih.gov/20479208.
^“Microbicide containing engineered bacteria may inhibit HIV-1” (英語). ScienceDaily. 2022年12月25日閲覧。
^“Cloning, expression, and characterization of the human eosinophil eotaxin receptor”. The Journal of Experimental Medicine183 (5): 2349–2354. (May 1996). doi:10.1084/jem.183.5.2349. PMC 2192548. PMID (8642344). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2192548/.
^ abc“Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils”. European Journal of Immunology31 (7): 2170–2178. (July 2001). doi:10.1002/1521-4141(200107)31:7<2170::AID-IMMU2170>3.0.CO;2-D. PMID (11449371).
^“Interaction of RANTES with syndecan-1 and syndecan-4 expressed by human primary macrophages”. Biochimica et Biophysica Acta (BBA) - Biomembranes1617 (1–2): 80–88. (October 2003). doi:10.1016/j.bbamem.2003.09.006. PMID (14637022).
^ ab“The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity”. The Journal of Biological Chemistry276 (14): 10620–10626. (April 2001). doi:10.1074/jbc.M010867200. PMID (11116158).
^“Distribution of functional polymorphic variants of inflammation-related genes RANTES and CCR5 in long-lived individuals”. Cytokine58 (1): 10–13. (April 2012). doi:10.1016/j.cyto.2011.12.021. PMID (22265023).
^“RANTES stimulates Ca2+ mobilization and inositol trisphosphate (IP3) formation in cells transfected with G protein-coupled receptor 75”. British Journal of Pharmacology149 (5): 490–497. (November 2006). doi:10.1038/sj.bjp.0706909. PMC 2014681. PMID (17001303). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2014681/.
^“Aggregation of RANTES is responsible for its inflammatory properties. Characterization of nonaggregating, noninflammatory RANTES mutants”. The Journal of Biological Chemistry274 (39): 27505–27512. (September 1999). doi:10.1074/jbc.274.39.27505. PMID (10488085).
^“CCL5-CCR5-mediated apoptosis in T cells: Requirement for glycosaminoglycan binding and CCL5 aggregation”. The Journal of Biological Chemistry281 (35): 25184–25194. (September 2006). doi:10.1074/jbc.M603912200. PMID (16807236).
^“A role for the chemokine RANTES in regulating CD8 T cell responses during chronic viral infection”. PLOS Pathogens7 (7): e1002098. (July 2011). doi:10.1371/journal.ppat.1002098. PMC 3141034. PMID (21814510). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3141034/.
^Glück, J.; Rogala, B. (1999). “Chemokine RANTES in atopic dermatitis”. Archivum Immunologiae Et Therapiae Experimentalis47 (6): 367–372. ISSN 0004-069X. PMID (10608293). https://pubmed.ncbi.nlm.nih.gov/10608293.
^Koya, Toshiyuki; Takeda, Katsuyuki; Kodama, Taku; Miyahara, Nobuaki; Matsubara, Shigeki; Balhorn, Annette; Joetham, Anthony; Dakhama, Azzedine et al. (2006-08). “RANTES (CCL5) regulates airway responsiveness after repeated allergen challenge”. American Journal of Respiratory Cell and Molecular Biology35 (2): 147–154. doi:10.1165/rcmb.2005-0394OC. ISSN 1044-1549. PMC 2643254. PMID (16528011). https://pubmed.ncbi.nlm.nih.gov/16528011.
関連文献
“HIV-1 Vpr and anti-inflammatory activity”. DNA and Cell Biology23 (4): 239–247. (April 2004). doi:10.1089/104454904773819824. PMID (15142381).