リノール酸ジオールシンターゼ（linoleate diol synthase）は、リノール酸代謝酵素の一つで、次の化学反応を触媒する酸化還元酵素である。
| リノール酸ジオールシンターゼ | |
|---|---|
| 識別子 | |
| EC番号 | 1.13.11.44 |
| データベース | |
| IntEnz | IntEnz view |
| BRENDA | BRENDA entry |
| ExPASy | NiceZyme view |
| KEGG | KEGG entry |
| MetaCyc | metabolic pathway |
| PRIAM | profile |
| PDB構造 | RCSB PDB PDBj PDBe PDBsum |
- リノール酸 + O2 (9Z,12Z)-(7S,8S)-ジヒドロキシオクタデカ-9,12-ジエン酸
反応式の通り、この酵素の基質はリノール酸とO2、生成物は(9Z,12Z)-(7S,8S)-ジヒドロキシオクタデカ-9,12-ジエン酸である。
組織名はlinoleate:oxygen 7S,8S-oxidoreductaseで、別名にlinoleate (8R)-dioxygenaseがある。
参考文献
- Brodowsky ID, Hamberg M, Oliw EH (1992). “A linoleic acid (8R)-dioxygenase and hydroperoxide isomerase of the fungus Gaeumannomyces graminis. Biosynthesis of (8R)-hydroxylinoleic acid and (7S,8S)-dihydroxylinoleic acid from (8R)-hydroperoxylinoleic acid”. J. Biol. Chem. 267 (21): 14738–45. PMID (1634517).
- Hamberg M, Zhang LY, Brodowsky ID, Oliw EH (1994). “Sequential oxygenation of linoleic acid in the fungus Gaeumannomyces graminis: stereochemistry of dioxygenase and hydroperoxide isomerase reactions”. Arch. Biochem. Biophys. 309 (1): 77–80. doi:10.1006/abbi.1994.1087. PMID (8117115).
- EH; Su, C; Osbourn, AE; Garosi, P; Hellman, U; Wernstedt, C; Oliw, EH (1999). “Cloning of linoleate diol synthase reveals homology with prostaglandin H synthases”. J. Biol. Chem. 274 (40): 28219–24. doi:10.1074/jbc.274.40.28219. PMID (10497176).
- Oliw EH, Su C, Skogstrom T, Benthin G (1998). “Analysis of novel hydroperoxides and other metabolites of oleic, linoleic, and linolenic acids by liquid chromatography-mass spectrometry with ion trap MSn”. Lipids. 33 (9): 843–52. doi:10.1007/s11745-998-0280-0. PMID (9778131).
- Su C, Oliw EH (1996). “Purification and characterization of linoleate 8-dioxygenase from the fungus Gaeumannomyces graminis as a novel hemoprotein”. J. Biol. Chem. 271 (24): 14112–8. doi:10.1074/jbc.271.24.14112. PMID (8662736).
- Su C, Sahlin M, Oliw EH (1998). “A protein radical and ferryl intermediates are generated by linoleate diol synthase, a ferric hemeprotein with dioxygenase and hydroperoxide isomerase activities”. J. Biol. Chem. 273 (33): 20744–51. doi:10.1074/jbc.273.33.20744. PMID (9694817).