一級アミンオキシダーゼ

一級アミンオキシダーゼ(primary-amine oxidase)は、次の化学反応を触媒する酸化還元酵素である。

一級アミンオキシダーゼ
識別子
EC番号	1.4.3.21
データベース
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB構造	RCSB PDB PDBj PDBe PDBsum
検索 PMC articles PubMed articles NCBI proteins
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RCH₂NH₂ + H₂O + O₂ ${\displaystyle \rightleftharpoons }$ RCHO + NH₃ + H₂O₂

反応式の通り、この酵素の基質はRCH₂NH₂とH₂OとO₂、生成物はRCHOとNH₃とH₂O₂である。

組織名はprimary-amine:oxygen oxidoreductase (deaminating)で、別名にamine oxidase (ambiguous); amine oxidase (copper-containing); amine oxidase (pyridoxal containing) (incorrect); benzylamine oxidase (incorrect); CAO (ambiguous); copper amine oxidase (ambiguous); Cu-amine oxidase (ambiguous); Cu-containing amine oxidase (ambiguous); diamine oxidase (incorrect); diamino oxhydrase (incorrect); histamine deaminase (ambiguous); histamine oxidase (ambiguous); monoamine oxidase (ambiguous); plasma monoamine oxidase (ambiguous); polyamine oxidase (ambiguous); semicarbazide-sensitive amine oxidase (ambiguous); SSAO (ambiguous)がある。

参考文献

• Haywood, G.W. and Large, P.J. (1981). “Microbial oxidation of amines. Distribution, purification and properties of two primary-amine oxidases from the yeast Candida boidinii grown on amines as sole nitrogen source.”. Biochem. J. 199: 187-201. PMID (7337701). 
• Tipping, A.J. and McPherson, M.J. (1995). “Cloning and molecular analysis of the pea seedling copper amine oxidase.”. J. Biol. Chem. 270: 16939-16946. PMID (7622512). 
• Lyles, G.A. (1996). “Mammalian plasma and tissue-bound semicarbazide-sensitive amine oxidases: biochemical, pharmacological and toxicological aspects.”. Int. J. Biochem. Cell Biol. 28: 259-274. PMID (8920635). 
• Wilce, M.C., Dooley, D.M., Freeman, H.C., Guss, J.M., Matsunami, H., McIntire, W.S., Ruggiero, C.E., Tanizawa, K. and Yamaguchi, H.. “Crystal structures of the copper-containing amine oxidase from Arthrobacter globiformis in the holo and apo forms: implications for the biogenesis of topaquinone.”. Biochemistry 36: 1997. PMID (9405045). 
• Lee, Y. and Sayre, L.M. (1998). “Reaffirmation that metabolism of polyamines by bovine plasma amine oxidase occurs strictly at the primary amino termini.”. J. Biol. Chem. 273: 19490-19494. PMID (9677370). 
• Houen, G. (1999). “Mammalian Cu-containing amine oxidases (CAOs): new methods of analysis, structural relationships, and possible functions.”. APMIS Suppl. 96: 1-46. PMID (10668504). 
• Andrés, N., Lizcano, J.M., Rodríguez, M.J., Romera, M., Unzeta, M. and Mahy, N. (2001). “Tissue activity and cellular localization of human semicarbazide-sensitive amine oxidase.”. J. Histochem. Cytochem. 49: 209-217. PMID (11156689). 
• Saysell, C.G., Tambyrajah, W.S., Murray, J.M., Wilmot, C.M., Phillips, S.E., McPherson, M.J. and Knowles, P.F. (2002). “Probing the catalytic mechanism of Escherichia coli amine oxidase using mutational variants and a reversible inhibitor as a substrate analogue.”. Biochem. J. 365: 809-816. PMID (11985492). 
• O'Sullivan, J., Unzeta, M., Healy, J., O'Sullivan, M.I., Davey, G. and Tipton, K.F. (2004). “Semicarbazide-sensitive amine oxidases: enzymes with quite a lot to do.”. Neurotoxicology 25: 303-315. PMID (14697905). 
• Airenne, T.T., Nymalm, Y., Kidron, H., Smith, D.J., Pihlavisto, M., Salmi, M., Jalkanen, S., Johnson, M.S. and Salminen, T.A. (2005). “Crystal structure of the human vascular adhesion protein-1: unique structural features with functional implications.”. Protein Sci. 14: 1964-1974. PMID (16046623).