CDKN2A |
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PDBに登録されている構造 |
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PDB | オルソログ検索: RCSB PDBe PDBj |
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PDBのIDコード一覧 |
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2A5E, 1A5E, 1BI7, 1DC2,%%s1A5E, 1BI7, 1DC2, 2A5E |
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識別子 |
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記号 | CDKN2A, CDK4I, CDKN2, CMM2, INK4, INK4A, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16, cyclin-dependent kinase inhibitor 2A, cyclin dependent kinase inhibitor 2A, Genes, p16, ARF. |
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外部ID | OMIM: 600160 MGI: 104738 HomoloGene: 55430 GeneCards: CDKN2A |
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遺伝子オントロジー |
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分子機能 | • NF-kappaB binding • 血漿タンパク結合 • cyclin-dependent protein serine/threonine kinase inhibitor activity • プロテインキナーゼ結合 • RNA結合 • DNA結合 • p53結合 • 転写因子結合 • MDM2/MDM4 family protein binding • ubiquitin-protein transferase inhibitor activity • SUMO transferase activity • disordered domain specific binding • ubiquitin ligase inhibitor activity
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細胞の構成要素 | • 細胞質 • 細胞質基質 • senescence-associated heterochromatin focus • 細胞核 • 核内構造体 • 核質 • 核小体 • ミトコンドリア • 高分子複合体
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生物学的プロセス | • positive regulation of smooth muscle cell apoptotic process • negative regulation of cyclin-dependent protein serine/threonine kinase activity • replicative senescence • G1期 • negative regulation of cell-matrix adhesion • 細胞老化 • negative regulation of cell growth • positive regulation of cellular senescence • positive regulation of macrophage apoptotic process • 細胞周期 • Ras protein signal transduction • negative regulation of phosphorylation • negative regulation of transcription, DNA-templated • negative regulation of NF-kappaB transcription factor activity • negative regulation of cell population proliferation • G1/S transition of mitotic cell cycle • negative regulation of G1/S transition of mitotic cell cycle • アポトーシス • regulation of G2/M transition of mitotic cell cycle • regulation of transcription, DNA-templated • タンパク質安定性の制御 • negative regulation of immature T cell proliferation in thymus • regulation of protein export from nucleus • negative regulation of protein kinase activity • negative regulation of proteolysis involved in cellular protein catabolic process • protein K63-linked ubiquitination • positive regulation of signal transduction by p53 class mediator • somatic stem cell division • タンパク質の安定化 • protein polyubiquitination • positive regulation of protein sumoylation • transcription, DNA-templated • positive regulation of transcription, DNA-templated • マイトファジー • apoptotic mitochondrial changes • regulation of protein targeting to mitochondrion • protein destabilization • negative regulation of ubiquitin-protein transferase activity • positive regulation of apoptotic process • rRNA processing • negative regulation of ubiquitin-dependent protein catabolic process • mitochondrial depolarization • positive regulation of DNA damage response, signal transduction by p53 class mediator • negative regulation of B cell proliferation • activation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of apoptotic DNA fragmentation • positive regulation of transcription by RNA polymerase II • positive regulation of protein localization to nucleus • protein sumoylation • positive regulation of gene expression • negative regulation of ubiquitin protein ligase activity • amyloid fibril formation • negative regulation of protein neddylation
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出典:Amigo / QuickGO |
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オルソログ |
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種 | ヒト | マウス |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | NM_000077 NM_001195132 NM_058195 NM_058196 NM_058197
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NM_001363763 |
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RefSeq (タンパク質) | NP_000068 NP_001182061 NP_478102 NP_478104 NP_001350692
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NP_478102.2 |
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NP_001035744 NP_034007 NP_034007.1 |
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場所 (UCSC) | Chr 9: 21.97 – 22 Mb | Chr 9: 89.19 – 89.21 Mb |
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PubMed検索 | [3] | [4] |
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ウィキデータ |
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