核内受容体コアクチベーター1

核内受容体コアクチベーター1 （NCOA1: nuclear receptor coactivator 1）は、いくつかの核内受容体相互作用ドメインと固有のヒストンアセチルトランスフェラーゼ活性を含む転写共調節タンパク質である。 NCOA1は、リガンドで活性化される核内受容体によってDNAプロモーター部位に動員される。次に、NCOA1はヒストンをアシル化し、下流のDNAを転写しやすくする。したがって、NCOA1はDNA発現の上方調節において核内受容体を援助する^[5][6]。

NCOA1
PDBに登録されている構造 PDB オルソログ検索: RCSB PDBe PDBj PDBのIDコード一覧 1FM6, 1FM9, 1K74, 1K7L, 1KV6, 1K4W, 1N4H, 1NQ7, 1NRL, 1P8D, 1PZL, 1RDT, 1TFC, 1U3R, 1U3S, 1X76, 1XIU, 1XV9, 1XVP, 1YY4, 1ZAF, 2A3I, 2C52, 2FVJ, 2GTK, 2HBH, 2HC4, 2HCD, 2HFP, 2NPA, 2NV7, 2P54, 2PRG, 3BEJ, 3BQD, 3CTB, 3CWD, 3DCT, 3DCU, 3DR1, 3ET1, 3ET3, 3FEI, 3FEJ, 3FUR, 3FXV, 3G8I, 3G9E, 3GYT, 3GYU, 3H0A, 3HC5, 3HC6, 3HVL, 3IPQ, 3IPS, 3IPU, 3KMR, 3LMP, 3OKH, 3OKI, 3OLF, 3OLL, 3OLS, 3OMK, 3OMM, 3OMO, 3OMP, 3OMQ, 3OOF, 3OOK, 3P88, 3P89, 3QT0, 3RUT, 3RUU, 3RVF, 3S9S, 3T03, 3UU7, 3UUA, 3UUD, 3V9Y, 3VN2, 4DK7, 4DK8, 4DM6, 4DM8, 4DQM, 4F9M, 4FGY, 4G1D, 4G1Y, 4G1Z, 4G20, 4G21, 4G2H, 4HEE, 4J5X, 4JYG, 4JYH, 4JYI, 4MG5, 4MG6, 4MG7, 4MG8, 4MG9, 4MGA, 4MGB, 4MGC, 4MGD, 4TUZ, 4TV1, 5AVI, 5AVL, 4Y29, 4RUJ, 4RUP, 5A86, 5E7V, 4UDB, 4UDA, 5AZT, 5HJS
識別子
記号	NCOA1, F-SRC-1, KAT13A, RIP160, SRC1, bHLHe42, bHLHe74, nuclear receptor coactivator 1
外部ID	OMIM: 602691 MGI: 1276523 HomoloGene: 7859 GeneCards: NCOA1
遺伝子の位置 (ヒト) 染色体 (2番染色体 (ヒト))^[1] バンド データ無し 開始点 24,491,254 bp^[1] 終点 24,770,702 bp^[1]
遺伝子の位置 (マウス) 染色体 12番染色体 (マウス)^[2] バンド データ無し 開始点 4,247,362 bp^[2] 終点 4,477,182 bp^[2]
RNA発現パターン さらなる参照発現データ
遺伝子オントロジー 分子機能 • transferase activity • DNA結合 • transcription coactivator activity • protein dimerization activity • protein N-terminus binding • 転写因子結合 • クロマチン結合 • histone acetyltransferase activity • 血漿タンパク結合 • androgen receptor binding • 酵素結合 • acyltransferase activity • nuclear receptor coactivator activity • aryl hydrocarbon receptor binding • nuclear receptor binding • estrogen receptor binding • DNA-binding transcription factor activity, RNA polymerase II-specific • progesterone receptor binding • retinoic acid receptor binding • protein-containing complex binding • retinoid X receptor binding 細胞の構成要素 • 細胞核 • 核質 • 細胞質基質 • 細胞膜 • 高分子複合体 • 細胞質 • neuron projection 生物学的プロセス • androgen receptor signaling pathway • regulation of RNA biosynthetic process • regulation of transcription, DNA-templated • cellular response to Thyroglobulin triiodothyronine • regulation of cellular response to drug • transcription, DNA-templated • positive regulation of transcription, DNA-templated • labyrinthine layer morphogenesis • positive regulation of neuron differentiation • bile acid and bile salt transport • positive regulation of apoptotic process • histone H4 acetylation • regulation of thyroid hormone mediated signaling pathway • positive regulation of transcription by RNA polymerase II • intracellular receptor signaling pathway • positive regulation of transcription from RNA polymerase II promoter by galactose • regulation of lipid metabolic process • transcription by RNA polymerase II • cellular response to hormone stimulus • 授乳 • 男性生殖腺発生 • ホルモンへの反応 • 小脳発生 • 海馬発生 • 視床下部発生 • 大脳皮質発生 • エストラジオールへの反応 • response to retinoic acid • response to progesterone • 発情周期 • positive regulation of female receptivity • male mating behavior 出典:Amigo / QuickGO
オルソログ
種	ヒト	マウス
Entrez	8648	17977
Ensembl	ENSG00000084676	ENSMUSG00000020647
UniProt	Q15788	P70365
RefSeq (mRNA)	NM_003743 NM_147223 NM_147233 NM_001362950 NM_001362952 NM_001362954 NM_001362955	NM_010881
RefSeq (タンパク質)	NP_003734 NP_671756 NP_671766 NP_001349879 NP_001349881 NP_001349883 NP_001349884	NP_035011
場所 (UCSC)	Chr 2: 24.49 – 24.77 Mb	Chr 2: 4.25 – 4.48 Mb
PubMed検索	^[3]	^[4]
ウィキデータ
閲覧/編集 ヒト 閲覧/編集 マウス

NCOA1は、ステロイド受容体コアクチベーター1（SRC-1: steroid receptor coactivator-1）と同一である。

相互作用分子

NCOA1は、塩基性ヘリックスループヘリックス（bHLH）ドメインを有しており、以下の生体分子と相互作用することができる。

• アンドロゲン受容体^[7][8][9]
• C-Fos^[10][11]
• (C-jun)^[10][11][12]
• (CIITA)^[13]
• (CREB結合タンパク質)^[14][15]
• サイクリンD1^[16]
• (DDX17)^[17]
• (DDX5)^[17]
• エストロゲン受容体α^{[14][17][18][19][20]}
• 糖質コルチコイド受容体^[21][22]
• (NFKB1)^[10][23]
• (PCAF)^[24]
• PPARGC1A^[25]
• (ペルオキシソーム増殖因子活性化受容体)α^[26][27]
• (SNW1)^[28]
• STAT3^[29]
• (STAT6)^[30][31]
• (TRIP4)^[32]
• (甲状腺ホルモン受容体)β^[33][34]

脚注

1. ^ ^{a b c} GRCh38: Ensembl release 89: ENSG00000084676 - Ensembl, May 2017
2. ^ ^{a b c} GRCm38: Ensembl release 89: ENSMUSG00000020647 - Ensembl, May 2017
3. ^ Human PubMed Reference:
4. ^ Mouse PubMed Reference:
5. ^ Sergio A. Oñate, Sophia Y. Tsai, Ming-Jer Tsai, Bert W. O'Malley (24 Nov 1995). “Sequence and characterization of a coactivator for the steroid hormone receptor superfamily”. Science 270 (5240): 1354–1357. doi:10.1126/science.270.5240.1354. PMID (7481822). 
6. ^ Sergio A. Onate, Viroj Boonyaratanakornkit, Thomas E. Spencer, Sophia Y. Tsai, Dean P. Edwards, Bert W. O'Malley (15 May 1998). “The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors”. Journal of Biological Chemistry 273 (20): 12101–12108. doi:10.1074/jbc.273.20.12101. PMID (9575154). 
7. ^ “Recruitment of beta-catenin by wild-type or mutant androgen receptors correlates with ligand-stimulated growth of prostate cancer cells”. Molecular Endocrinology 18 (10): 2388–2401. (1 October 2004). doi:10.1210/me.2003-0436. PMID (15256534). 
8. ^ “Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells”. Journal of Biological Chemistry 277 (41): 38087–38094. (11 October 2002). doi:10.1074/jbc.M203313200. PMID (12163482). 
9. ^ “The AF1 and AF2 domains of the androgen receptor interact with distinct regions of SRC1”. Molecular and Cellular Biology 19 (12): 8383–8392. (Dec 1999). doi:10.1128/mcb.19.12.8383. PMC 84931. PMID (10567563). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC84931/. 
10. ^ ^{a b c} “Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2”. Molecular Endocrinology 14 (6): 915–925. (1 June 2000). doi:10.1210/mend.14.6.0471. PMID (10847592). 
11. ^ ^{a b} “Steroid receptor coactivator-1 coactivates activating protein-1-mediated transactivations through interaction with the c-Jun and c-Fos subunits”. Journal of Biological Chemistry 273 (27): 16651–16654. (1998 Jul 3). doi:10.1074/jbc.273.27.16651. PMID (9642216). 
12. ^ “A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo”. Journal of Biological Chemistry 274 (48): 34283–34293. (26 November 1999). doi:10.1074/jbc.274.48.34283. PMID (10567404). 
13. ^ “Steroid receptor coactivator 1 links the steroid and interferon gamma response pathways”. Molecular Endocrinology 17 (12): 2509–2518. (01 December 2003). doi:10.1210/me.2002-0439. PMID (12933903). 
14. ^ ^{a b} “Analysis of the steroid receptor coactivator 1 (SRC1)-CREB binding protein interaction interface and its importance for the function of SRC1”. Molecular and Cellular Biology 21 (1): 39–50. (2001 Jan). doi:10.1128/MCB.21.1.39-50.2001. PMC 86566. PMID (11113179). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC86566/. 
15. ^ “Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase”. Molecular and Cellular Biology 22 (10): 3549–3461. (May 2002). doi:10.1128/MCB.22.10.3549-3561.2002. PMC 133790. PMID (11971985). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC133790/. 
16. ^ “Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1”. Genes & Development 12 (22): 3488–3498. (1998 Nov 15). doi:10.1101/gad.12.22.3488. PMC 317237. PMID (9832502). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC317237/. 
17. ^ ^{a b c} “A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA”. EMBO Journal 20 (6): 1341–1352. (15 March 2001). doi:10.1093/emboj/20.6.1341. PMC 145523. PMID (11250900). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC145523/. 
18. ^ “BRG-1 is recruited to estrogen-responsive promoters and cooperates with factors involved in histone acetylation”. Molecular and Cellular Biology 20 (20): 7541–7549. (Oct 2000). doi:10.1128/MCB.20.20.7541-7549.2000. PMC 86306. PMID (11003650). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC86306/. 
19. ^ “Isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptor”. EMBO Journal 17 (1): 232–243. (1998 Jan 2). doi:10.1093/emboj/17.1.232. PMC 1170374. PMID (9427757). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1170374/. 
20. ^ “The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro”. Proceedings of the National Academy of Sciences, USA 99 (5): 2642–2647. (March 5, 2002). doi:10.1073/pnas.261715899. PMC 122401. PMID (11867769). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC122401/. 
21. ^ “Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140”. Molecular Endocrinology 15 (4): 501–511. (1 April 2001). doi:10.1210/mend.15.4.0624. PMID (11266503). 
22. ^ “A point mutation of the AF2 transactivation domain of the glucocorticoid receptor disrupts its interaction with steroid receptor coactivator 1”. Journal of Biological Chemistry 277 (29): 26098–260102. (2002 Jul 19). doi:10.1074/jbc.M204013200. PMID (12118039). 
23. ^ “Steroid receptor coactivator-1 interacts with the p50 subunit and coactivates nuclear factor kappaB-mediated transactivations”. Journal of Biological Chemistry 273 (18): 10831–10834. (1998 May 1). doi:10.1074/jbc.273.18.10831. PMID (9556555). 
24. ^ “Steroid receptor coactivator-1 is a histone acetyltransferase”. Nature 389 (6647): 194–198. (11 September 1997). doi:10.1038/38304. PMID (9296499). 
25. ^ “Activation of PPARgamma coactivator-1 through transcription factor docking”. Science 286 (5443): 1368–1371. (12 Nov 1999). doi:10.1126/science.286.5443.1368. PMID (10558993). 
26. ^ “p300 functions as a coactivator for the peroxisome proliferator-activated receptor alpha”. Journal of Biological Chemistry 272 (52): 33435–33443. (26 December 1997). doi:10.1074/jbc.272.52.33435. PMID (9407140). 
27. ^ “A regulatory role for RIP140 in nuclear receptor activation”. Molecular Endocrinology 12 (6): 864–881. (01 June 1998). doi:10.1210/mend.12.6.0123. PMID (9626662). 
28. ^ “Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription”. Journal of Biological Chemistry 276 (44): 40614–40620. (2 Nov 2001). doi:10.1074/jbc.M106263200. PMID (11514567). 
29. ^ “Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a”. Journal of Biological Chemistry 277 (10): 8004–811. (8 Mar 2002). doi:10.1074/jbc.M111486200. PMID (11773079). 
30. ^ “Transcriptional activation by STAT6 requires the direct interaction with NCoA-1”. Journal of Biological Chemistry 276 (49): 45713–45721. (7 Dec 2001). doi:10.1074/jbc.M108132200. PMID (11574547). 
31. ^ “An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1”. Journal of Biological Chemistry 277 (39): 36052–36060. (27 Sep 2002). doi:10.1074/jbc.M203556200. PMID (12138096). 
32. ^ “Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation”. Molecular and Cellular Biology 19 (9): 6323–6332. (Sep 1999). doi:10.1128/mcb.19.9.6323. PMC 84603. PMID (10454579). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC84603/. 
33. ^ “Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors”. Endocrinology 139 (10): 4197–4204. (1 Oct 1998). doi:10.1210/endo.139.10.6218. PMID (9751500). 
34. ^ “Analysis of the functional role of steroid receptor coactivator-1 in ligand-induced transactivation by thyroid hormone receptor”. Molecular Endocrinology 11 (6): 755–767. (1 Jun 1997). doi:10.1210/mend.11.6.0003. PMID (9171239). 

外部リンク

• (nuclear receptor coactivator 1) - MeSH・アメリカ国立医学図書館・生命科学用語シソーラス（英語）
• NURSA C89

参考文献

• “Peroxisome proliferator-activated receptors, coactivators, and downstream targets”. (Cell Biochemistry and Biophysics). 32 Spring (1–3): 187–204. (2001). doi:10.1385/cbb:32:1-3:187. PMID (11330046).